Gd's promise to Isaac was for a limited territory, unlike the promise to Jacob: Shabbat 118b
Isaac and his sons, Jacob and Esav
Avimelech's "blessing" to Sarah resulted in Isaac's blindness: Megillah 15a, 28a
Looking at Esav caused Isaac's blindness: Megillah 28a
The pleasant smell which he reported on Jacob before blessing him was that of an apple orchard: Taanit 29b
The pleasant smell which he reported on Jacob before blessing him was that of citrons: Tos. Taanit 29b #2
Isaac's hopes for Esav, and Gd's response to Isaac: Megillah 6a
The Jews not wanting to rely on Isaac's mercy in the Future, because he didn't ask for mercy when he blessed Esav: Shabbat 89b
Isaac's Merit, and his Descendants
Isaac as the true descendant of Avraham: Nedarim 31a
Isaac's merit saves the Jews from Hell: Shabbat 104a
The meal in the future for the righteous will be in Isaac's merit: Pesachim 119b
Isaac Defending the Jews in the future, pointing to the Jews' promise of "Na'aseh VeNishma [We will Practice and We Will Listen]" and pointing to the percent of the day not involved in Sin, and offering to take some of the brunt himself: Shabbat 89b